Genetic Polymorphism of GSTM1 as risk factor for Oral Potentially Malignant Disorder
نویسندگان
چکیده
Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic metabolising enzymes crucial to carcinogen and drug metabolism and lead to variations in their activity. These enzymes increase the risk of cancer by an altered action on environmental carcinogens. Tobacco abuse is a well‐known risk factor for potentially malignant disorders. Factors that influence tobacco‐exposed individuals developing a malignancy may include the combination of total tobacco exposure and genetic susceptibility. The objective of this study was to analyse the significance of genetic polymorphisms in GSTM1(carcinogen metabolizing enzymes) genes in patients with Oral Submucous Fibrosis(OSMF). Method: The study subjects included 50 patients. 25 were diagnosed with OSMF, 5 with malignant transformation in OSMF and 20 age and sex matched healthy controls, Genotypes of GSTM1 were determined by PCR-RFLP( Polymerase Chain reactionRestricted Frequency Length Polymorphism). Results: 10%, 40% and 60% GSTM1 null genotype was observed in normal subjects, OSMF patients and OSMF patients with malignancy respectively. Conclusion: Polymorphism in GSTM1 null genotype may confer an increased risk for developing Oral Submucous Fibrosis.
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